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KMID : 1011620200360020196
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Korean Journal of Food and Cookey Science
2020 Volume.36 No. 2 p.196 ~ p.204
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Effect of Green Tea Extract on Diabetic Dyslipidemia in Rats
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Shin Kun-Soo
Park Pyoung-Sim
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Abstract
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Purpose: The purpose of this study was to evaluate the effect of green tea extract(GTE) on diabetic dyslipidemia in rats.
Methods: The experimental group was divided into three groups, the none diabetic control (NC) group, the diabetes mellitus (DM) group, and the diabetes mellitus+GTE (DM+GTE) group. Diabetes mellitus was induced by high fat diet and low dose streptozotocin administration. GTE was dissolved in the drinking water at 0.2% concentration and it was orally administered for 16 weeks. The food and water intake were monitored on a daily basis, while the fasting blood glucose levels and body weight were measured weekly. After 16 weeks, the biochemical parameters were observed, and the gene expression levels of the lipid metabolism-related enzymes in the liver and soleus muscle of the rats were examined by RNA-seq method.
Results: The GTE administration decreased the levels of fasting blood glucose in the diabetic groups (an average of 22%). Decreased levels of serum triglyceride (22%), total cholesterol (24%), and free fatty acid (23%) were observed in the DM+GTE group. The expression levels of hepatic acyl-CoA synthetase (Acsm2a) and the acyl-CoA synthetase family member 2 (Acsf2) genes were decreased whereas the expression levels of 5'-AMP-activated protein kinase catalytic subunit alpha-2 (Prkaa2), acyl-CoA desaturase 1 (Scd1) and acetyl-CoA carboxylase alpha (Acaca) were increased in the livers of DM+GTE group.
Conclusion: These results suggest that GTE are effective in alleviating dyslipidemia caused by diabetes mellitus, and the increased expression of Prkaa2 and Acaca in liver tissues by GTE is considered to be a factor in improving diabetic dyslipidemia.
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KEYWORD
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diabetes mellitus, green tea extract, dyslipidemia
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